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December 23, 2022
In 2023, the Department of Veterans Affairs will embark on a study to find out the simplest screening approach for liver cancer, a lethal cancer that may be cured if caught early. This is the largest scientific trial in historical past associated to liver cancer screening.
The study will decide whether or not detecting liver cancer earlier with abbreviated MRI could make a distinction for sufferers’ danger of demise. Better often known as PREMIUM — PREventing Liver Cancer Mortality via Imaging with Ultrasound vs. MRI — the trial’s goal is to find out whether or not screening with abbreviated magnetic resonance imaging is best than ultrasound, the present commonplace of care in lowering liver cancer deaths in veterans.
“This sort of huge, multicenter trial might solely be carried out in VA? the largest built-in well being care system within the nation,” mentioned Assistant Under Secretary of Health for Discovery, Education and Affiliate Networks Carolyn M. Clancy, M.D. “VA has a excessive prevalence of sufferers with superior liver illness who may benefit from screening for liver cancer. The study has the potential to vary scientific follow for tens of hundreds of veterans and non-veterans alike, and it might reply key questions on liver cancer screening which have been debated for greater than three many years.”
Liver cancer is the sixth main explanation for cancer-related demise within the United States. The PREMIUM trial will recruit 4,700 veterans with cirrhosis (liver scarring attributable to a number of totally different situations) from 47 VA medical facilities.
VA’s Veterans Health Administration is the largest well being care supplier within the United States for sufferers with cirrhosis, a number one danger issue for liver cancer. Enrollment will start in 2023 and observe contributors over an 8-12 months interval. This is the primary scientific trial to check the 2 screening strategies (ultrasound and MRI) for impact on affected person demise.
Ultrasound has lengthy been the usual of look after liver cancer screening. However, its high quality can range considerably relying on the individual doing the process and the physique sort of the affected person. MRI is the gold commonplace for detecting liver cancer as soon as a mass is detected on ultrasound. Abbreviated MRI, a a lot shorter process than commonplace MRI, has proven promise in detecting liver cancer at early levels. For extra data, go to www.vacsp.analysis.va.gov.
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